The main difference is that the Honda GX-series engines are commercial duty while the GC160 is considered residential duty.

Other differences:

• GX-series engines have low-oil shut-offs, which prevent damage to the engine.
• The GC160 engine has an aluminum bore where the GX-series have cast iron bores, giving the Honda GX- engines a longer life.
• GX-series have fuel-shutoff valve so that if they are run infrequently you can run the fuel out, which is easier on the carburetor.
• GX-series have on/off switch where the GC-series have on/off combined into the throttle control.
• You'll find a lot of metal on the GX-series and plastic on the GC. For example, the gas tank on the GC is plastic; on the GX-series it’s steel.
• A bonus of the GX-series engines is that models GX160 and GX200 (and while our supply lasts, GX120), are available with an integral power supply unit allowing the Point of Entry Safety Light option. Because the POE Safety Light is wired directly to an alternator in the engine, it is not available on the economy GC160 or as an add-on to existing fans.
• For commercial use, Honda warranties the GX-series engines for 36 months and the GC engine for 3 months.
• GX-series engines are generally made in Thailand but GC-series engines are made in the USA.

Below: Honda GC-series engine